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Biological Safety Cabinets Selection

Views: 14     Author: Site Editor     Publish Time: 2024-05-06      Origin: Site

Biological safety cabinets selection issues

3和4生物安全柜-封面

Biological safety cabinets (Biological safety cabinets, BSC) is the most basic safety protection equipment in the laboratory biosafety primary protection barrier, which belongs to Class III medical devices.Decree No.424 of the State Council issued in 2004 and the national standard GB19489-2004 have clearly pointed out that, Biological safety cabinets are the main safety equipment essential to the protection of staff. The State Council Decree 424 and the national standard GB19489-2004, both issued in 2004, clearly state that the biological safety cabinet is the main safety equipment indispensable for the protection of staff.

 

However, it is worrying that, at present, the industry in the understanding of biological safety cabinets, selection, use and so on, there are many problems, thus bringing great potential danger to the biological safety protection.

Selection of inaccurate bring unbearable weight biological safety cabinet is for the operation of primary cultures, bacterial strains and diagnostic specimens and other infectious experimental materials, used to protect the operator himself, the laboratory environment and experimental materials, so that it avoids exposure to infectious aerosols and spattering may be generated in the course of the operation of the above products designed.

Depending on the type of samples to be operated and the range of airspace that may be affected, the structural design of the biological safety cabinets and the ratio of air exhaust are also different. Accordingly, biological safety cabinets are categorized into Class I, Class II and Class III, of which Class II is further divided into types A1, A2, B1 and B2.

 

Shaanxi Blood Center senior engineer, Shaanxi Medical Devices Industry Association, vice president of the hospital equipment branch Zhang Yaocan emphasized that the basic principle of selection of biological safety cabinets is appropriate. Different safety levels of the laboratory should be selected at different levels, different models of biological safety cabinets, but also according to the protection, protection of different types to choose. In general, in the operation of a small number of volatile chemical reagents or radionuclides, you can choose B1 type biological safety cabinets; operation of a large number of volatile chemical reagents or radionuclides, you must use B2 type biological safety cabinets. At present, the most widely used is the A2 type safety cabinets, which can fully meet the daily use of general hospitals, energy saving, more economical.

 

Selection must not be ahead of time, ahead of time must be inaccurate, inaccurate will bring unbearable weight.Zhang Yaocan said, in the case of A2 type can meet the application, blindly choose B2 type, the problem then came. B2 type safety cabinet 100% external exhaust, exhaust volume can reach about 1500 cubic meters per hour (model different differences), ordinary household exhaust fan exhaust volume of about 80 cubic meters per hour, the difference between the two more than ten times. If the room does not have enough supplementary air volume, the safety cabinet simply can not work properly. Open the door of the laboratory room, and does not meet the laboratory specification requirements. In addition, a large amount of air in the room is exhausted, to ensure that the temperature in the laboratory to meet the requirements of the experiment, the need for both chiller and heater load is very large. If the laboratory has been built can not meet the requirements of indoor insulation and supplemental air volume, it is necessary to invest a lot of money to carry out renovation, and the future operating costs are also very high.


Cautious view of publicity selling points

Zhang Yaocan pointed out that in the face of brand publicity selling point, to be specifically analyzed. The choice of biological safety cabinets is first of all the appropriate type, followed by high-efficiency filters, air circuit design, alarm devices, negative pressure protection and other indicators for comparison, installation, training, after-sales service is also very important. For example, usually electric, automatic control is a sign of the sophistication of the equipment, but the biological safety cabinets with electric front window should be specifically analyzed - in the case of biological safety cabinets without dual-channel power supply system (or timely switching of the backup power supply, or delayed power supply in the machine settings), if a sudden blackout, the electric front window will not be able to close, which may lead to the leakage of hazardous materials and cause contamination. Furthermore, the operating height is fixed for both motorized and manual windows. Therefore, this potentially dangerous motorized front window feature is of little significance to the average health facility.

Can not replace the safety cabinet with a clean bench some professionals reflect that some hospitals should now use biological safety cabinets in the place of the use of medical clean bench, many operators believe that the two devices have the same shape, the role of the same, the daily operation of the samples are ordinary samples, does not have a highly pathogenic and infectious.

 

In this regard, Zhang Yaocan emphasized that there is an essential difference between a biological safety cabinet and a clean bench: a clean bench is a device that only protects samples by blowing purified air from a high-efficiency filter downward through the work area. Since the working area is a positive pressure area, the airflow is spilled out through the operation window, therefore, it does not protect the operator and the environment. If the operating sample contains known, unknown or potentially pathogenic bacteria, it is likely to pose a hazard to the operator and the environment. In contrast, a biosafety cabinet is a negative-pressure filtered exhaust cabinet where the exhaust gases are rigorously filtered by a high-efficiency filter, which protects the operator and the environment from being exposed to the harmful aerosols generated during the experiment. Proper operation of a biological safety cabinet protects the operator, the samples and the working environment. Therefore, the use of clean bench to replace the biological safety cabinet of the relevant medical units and laboratories should be re-assessed laboratory microbial risk, such as the potential danger to the operators and the environment, should be replaced in a timely manner the original clean bench, and according to the different needs of the appropriate type of biological safety cabinet.


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